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SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

2.965,00 €

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ArtNr	NS0-C51W3-1mg
Hersteller	ACROBiosystems
Menge	1mg
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid
Specific against	SARS-CoV-2
Konjugat/Tag	His; Strep
Purity	>90% as determined by SDS-PAGE.
Dry ice	Yes
Citations	(1) Wang Y, et al. J Virol. 2015. 89(16):8416-27.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	NSP16 & NSP10,nsp16 & nsp10,COVID-19
Lieferbar
Buffer	PBS, pH7.4
Characteristics	SARS-CoV-2 NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag is produced by co-expression of NSP16 and NSP10, has a calculated MW of 35.3 kDa (NSP16) and 18.3 kDa (NSP10). Subunit NSP16 is fused with a polyhistidine tag at the N-terminus and subunit
Description	NSP10, Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and 2'-O-methyltransferase (NSP16) activities. Therefore plays an essential role in viral mRNAs cap methylation. 2'-O-methyltransferase (NSP16) that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities.
Endotoxin Level	Less than 1.0 EU per ug by the LAL method.
Exp Region	Ser 1 - Asn 298 (NSP16) & Ala 1 - Gln 139 (NSP10)
Molecular Weight	35.3 kDa (NSP16) & 18.3 kDa (NSP10)
Molecule	NSP16 & NSP10
Shipping condition	Liquid, -70CDry ice
Storage	-70C

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