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SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

SARS-CoV-2 (COVID-19) NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag

€2,965.00

Excl. VAT

Item no.	NS0-C51W3-1mg
Manufacturer	ACROBiosystems
Amount	1mg
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	SARS-CoV-2
Conjugate/Tag	His; Strep
Purity	>90% as determined by SDS-PAGE.
Dry ice	Yes
Citations	(1) Wang Y, et al. J Virol. 2015. 89(16):8416-27.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	NSP16 & NSP10,nsp16 & nsp10,COVID-19
Available
Buffer	PBS, pH7.4
Characteristics	SARS-CoV-2 NSP16&NSP10 Heterodimer Protein, His Tag&Twin Strep Tag is produced by co-expression of NSP16 and NSP10, has a calculated MW of 35.3 kDa (NSP16) and 18.3 kDa (NSP10). Subunit NSP16 is fused with a polyhistidine tag at the N-terminus and subunit
Description	NSP10, Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and 2'-O-methyltransferase (NSP16) activities. Therefore plays an essential role in viral mRNAs cap methylation. 2'-O-methyltransferase (NSP16) that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system. Nsp10 forms a dodecamer and interacts with nsp14 and nsp16; these interactions enhance nsp14 and nsp16 enzymatic activities.
Endotoxin Level	Less than 1.0 EU per ug by the LAL method.
Exp Region	Ser 1 - Asn 298 (NSP16) & Ala 1 - Gln 139 (NSP10)
Molecular Weight	35.3 kDa (NSP16) & 18.3 kDa (NSP10)
Molecule	NSP16 & NSP10
Shipping condition	Liquid, -70CDry ice
Storage	-70C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.