CTLA-4 Protein, Human (HEK293, Fc)

CTLA-4 Protein, a pivotal inhibitory receptor, is a principal negative regulator orchestrating T-cell responses in immune modulation. Its distinctive property lies in significantly heightened affinity for B7 ligands (CD80/CD86) compared to CD28. This difference positions CTLA-4 to competitively engage with CD80/B7-1 and CD86/B7.2, suppressing T-cell activation and finely tuning immune responses. The homodimeric structure, intricately linked by disulfide bonds, underscores its role as a molecular sentinel. Additionally, CTLA-4 interacts with ICOSLG, contributing to its multifaceted engagement in immune checkpoint pathways. CTLA-4 Protein, Human (HEK293, Fc) is the recombinant human-derived CTLA-4 protein, expressed by HEK293, with C-hFc labeled tag. The total length of CTLA-4 Protein, Human (HEK293, Fc) is 126 a.a., with molecular weight of ~50-58 kDa.

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Recombinant Proteins