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Biotin Anti-Mouse IL-2 (JES6-5H4)

Biotin Anti-Mouse IL-2 (JES6-5H4)

€40.00

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Item no.	30-7021-U025
Manufacturer	Tonbo Biosciences
Amount	25 ug
Category	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cell Culture Cytokines Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	Biotin
Applications	FC
Clone	JES6-5H4
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b kappa
Conjugate/Tag	Biotin
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Interleukin-2
Similar products	JES6-5H4
Available
Description	The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling. The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralizing reagent in vitro and in vivo.
Alternative Names	Interleukin-2
Gene ID	16183
Citations	Attridge K, Wang CJ, Wardzinski L, Kenefeck R, Chamberlain JL, Manzotti C, Kopf M, and Walker LSK. 2012. Blood. 119: 4656-4664. (Flow cytometry) Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, and Amsen D. 2012. Proc. Natl. Acad. Sci. 109: 9041-9046. (ELISA - detection) Chen Q, Kiim YC, Laurence A, Punkosdy GA, and Shevach EM. 2011. J. Immunol. 186: 6329-6337. (in vivo blocking) Weber KS, Hildner K, Murphy KM and Allen PM. 2010 J. Immunol. 185: 2836-2846. (ELISA) Wang C, Morley SC, Donermeyer D, Peng I, Lee WP, Devoss J, Damilenko DM, Lin Z, Zhang J, Zhou J, Allen PM, and Brown EJ. 2010. J. Immunol. 185: 7487-7497. (Immunocytochemistry/Immunofluorescence microscopy) Cardona AE and Teale JM. 2002. J. Immunol. 169: 3163-3171. (Immunohistochemistry - frozen tissue) Woo AL, Gildea LA, Tack LM, Miller ML, Spicer A, Millhorn DE, Finkelman FD, Dassett DJ, and Shull GE. 2002. J. Biol. Chem. 277: 49036-49046. (in vivo blocking)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 ug

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Delivery expected until 9/11/2025

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