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Biotin Anti-Mouse IL-2 (JES6-5H4)

Biotin Anti-Mouse IL-2 (JES6-5H4)

40,00 €

Zzgl. MwSt.

ArtNr	30-7021-U025
Hersteller	Tonbo Biosciences
Menge	25 ug
Kategorie	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cell Culture Cytokines Flow Cytometry Primary Antibodies
Typ	Antibody Monoclonal
Format	Biotin
Applikationen	FC
Clon	JES6-5H4
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b kappa
Konjugat/Tag	Biotin
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Interleukin-2
Similar products	JES6-5H4
Lieferbar
Description	The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling. The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralizing reagent in vitro and in vivo.
Alternative Names	Interleukin-2
Gene ID	16183
Citations	Attridge K, Wang CJ, Wardzinski L, Kenefeck R, Chamberlain JL, Manzotti C, Kopf M, and Walker LSK. 2012. Blood. 119: 4656-4664. (Flow cytometry) Helbig C, Gentek R, Backer RA, de Souza Y, Derks IAM, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, and Amsen D. 2012. Proc. Natl. Acad. Sci. 109: 9041-9046. (ELISA - detection) Chen Q, Kiim YC, Laurence A, Punkosdy GA, and Shevach EM. 2011. J. Immunol. 186: 6329-6337. (in vivo blocking) Weber KS, Hildner K, Murphy KM and Allen PM. 2010 J. Immunol. 185: 2836-2846. (ELISA) Wang C, Morley SC, Donermeyer D, Peng I, Lee WP, Devoss J, Damilenko DM, Lin Z, Zhang J, Zhou J, Allen PM, and Brown EJ. 2010. J. Immunol. 185: 7487-7497. (Immunocytochemistry/Immunofluorescence microscopy) Cardona AE and Teale JM. 2002. J. Immunol. 169: 3163-3171. (Immunohistochemistry - frozen tissue) Woo AL, Gildea LA, Tack LM, Miller ML, Spicer A, Millhorn DE, Finkelman FD, Dassett DJ, and Shull GE. 2002. J. Biol. Chem. 277: 49036-49046. (in vivo blocking)

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 25 ug

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