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mgcd-265-analog

mgcd-265-analog

Item no.	V0520-500mg
Manufacturer	InvivoChem LLC
CASRN	875337-44-3
Amount	500mg
Category	Cell Biology Cell Stainings Reagents & Chemicals Nuclear Molecules
Type	Biochemicals
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0520CAS #:875337-44-3Purity >=98% Description: MGCD-265 analog (Glesatinib analog) is a potent, orally bioavailable, and ATP-competitive multi-kinase inhibitor with potential antitumor activity. It inhibits c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively. MGCD265 analog has been studied in clinical trials for patients with advanced solid tumors including NSCLC, as a monotherapy and in combination with either docetaxel or erlotinib. In a phase I study, MGCD265 analog was given orally from 24 mg/m2 daily to 235 mg/m2 twice daily uninterrupted to patients with advanced solid malignancy until disease progression. Description: References: Bioorg Med Chem Lett. 2008 May 1; 18(9):2793-8; J Clin Oncol 28, 2010 (suppl; abstr e13595). References:
Molecular Weight (MW)	517.60
Formula	C26H20FN5O2S2
CAS No.	875337-44-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 104 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	Chemical Name: N-((3-fluoro-4-((2-(1-methyl-1H-imidazol-4-yl)thieno[3, 2-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-phenylacetamide InChi Key: UFICVEHDQUKCEA-UHFFFAOYSA-N InChi Code: InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10, 12-15H, 11H2, 1H3, (H2, 30, 31, 33, 35) SMILES Code: O=C(NC(NC1=CC=C(OC2=C3C(C=C(C4=CN(C)C=N4)S3)=NC=C2)C(F)=C1)=S)CC5=CC=CC=C5
Synonyms	MGCD265-analog; Glesatinib-analog; MGCD-265-analog; MGCD 265-analog;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 500mg

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Delivery expected until 8/7/2025

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