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Amodiaquine dihydrochloride dihydrate

Amodiaquine dihydrochloride dihydrate

€72.00

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Item no.	HY-B1322-10mM
Manufacturer	MedChem Express
CASRN	6398-98-7
Amount	10 mM/1 mL
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.89
Formula	C20H22ClN3O.2H2O.2HCl
Citations	Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. Biol Pharm Bull. 2022 Feb 3. Cell Rep. 2021 Apr 6;35(1):108959. Metab Brain Dis. 2021 Jan 28. Research Square Print. September 20th, 2022. Oxid Med Cell Longev. 2021 Feb 10. Pharmacol Res. 2023 Mar 20;106717. [1]Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. [2]Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. [3]Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. [4]M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8.
Smiles	OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CN(CC)CC.Cl.Cl.O.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Amodiaquin (dihydrochloride dihydrate)
Available
Product Description	Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine dihydrochloride dihydrate is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	464.81
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 20 mg/mL (ultrasonic)
Isoform	Plasmodium
Pathway	Anti-infection; Epigenetics
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B1322-10mM-safety-datasheet.pdf