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Clemastine fumarate

Clemastine fumarate

€72.00

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Item no.	HY-B0298A-10mM
Manufacturer	MedChem Express
CASRN	14976-57-9
Amount	10 mM/1 mL
Category	Food Safety Histamines Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.93
Formula	C25H30ClNO5
Citations	Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. Cell Prolif. 2021 Jan;54(1):e12953. Microbiol Spectr. 2022 Mar 2;e0054121. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Nov 28:110901. Viruses. 2021 Jun 28;13(7):1255. Methods Mol Biol. 2023;2683:103-111. [1]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017. [2]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.
Smiles	CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HS-592 (fumarate); Meclastine (fumarate)
Available
Product Description	Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	459.96
Clinical Information	Launched
Solubility	DMSO : 14.29 mg/mL (ultrasonic)\|H2O : 0.67 mg/mL (ultrasonic)
Isoform	H1 Receptor
Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-B0298A-10mM-safety-datasheet.pdf