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Rosuvastatin Calcium

Rosuvastatin Calcium

€30.00

Excl. VAT

Item no.	HY-17504-10mg
Manufacturer	MedChem Express
CASRN	147098-20-2
Amount	10 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.94
Formula	C22H27Ca0.5FN3O6S
Citations	Acta Pharmacol Sin. 2023 Jan 31. Front Bioeng Biotechnol. 2022 Mar 17;10:826093. Front Cell Dev Biol. 2022 Mar 3;10:806081. Eur J Pharmacol. 2023 Jul 13;955:175911. Exp Ther Med. August 17, 2021. Front Cell Dev Biol. 2021 May 6;9:651579. Front Oncol. 10 May 2021. Front Oncol. 2021 May 10;11:595285. J Inflamm Res. 2021,14: 1537-1549. [1]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [2]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [3]Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78. [4]Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.
Smiles	O=C([O-])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2.[0.5Ca2+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Rosuvastatin hemicalcium; ZD 4522 Calcium
Available
Product Description	Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	500.57
Clinical Information	Launched
Solubility	DMSO : 25 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic)
Pathway	Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-17504-10mg-safety-datasheet.pdf