Rosuvastatin Calcium

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ArtNr	HY-17504-10mg
Hersteller	MedChem Express
CAS-Nr.	147098-20-2
Menge	10 mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.94
Formula	C22H27Ca0.5FN3O6S
Citations	Acta Pharmacol Sin. 2023 Jan 31. Front Bioeng Biotechnol. 2022 Mar 17;10:826093. Front Cell Dev Biol. 2022 Mar 3;10:806081. Eur J Pharmacol. 2023 Jul 13;955:175911. Exp Ther Med. August 17, 2021. Front Cell Dev Biol. 2021 May 6;9:651579. Front Oncol. 10 May 2021. Front Oncol. 2021 May 10;11:595285. J Inflamm Res. 2021,14: 1537-1549. [1]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [2]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [3]Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78. [4]Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.
Smiles	O=C([O-])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2.[0.5Ca2+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Rosuvastatin hemicalcium; ZD 4522 Calcium
Lieferbar
Product Description	Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	500.57
Clinical Information	Launched
Solubility	DMSO : 25 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic)
Pathway	Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-17504-10mg-safety-datasheet.pdf