FIPI

€92.00

Excl. VAT

Item no.	HY-12807-10mM
Manufacturer	MedChem Express
CASRN	939055-18-2
Amount	10 mM/1 mL
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Neural Signaling Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules By Organ Bone Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.82
Formula	C23H24FN5O2
Citations	[1]Su W, et al. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol. 2009 Mar;75(3):437-46. [2]Secor JD, et al. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid si [3]Monovich L, et al. Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1.
Smiles	O=C(C(N1)=CC2=C1C=CC(F)=C2)NCCN3CCC(N4C5=CC=CC=C5NC4=O)CC3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	5-Fluoro-2-indolyl deschlorohalopemide
Available
Product Description	FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	421.47
Clinical Information	No Development Reported
Solubility	DMSO : 14.67 mg/mL (ultrasonic; warming)
Pathway	Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-12807-10mM-safety-datasheet.pdf