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Hydroxychloroquine sulfate

Hydroxychloroquine sulfate

€59.00

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Item no.	HY-B1370-50mg
Manufacturer	MedChem Express
CASRN	747-36-4
Amount	50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.99
Formula	C18H28ClN3O5S
Citations	ACS Appl Mater Interfaces. 2022 Oct 27. Acta Pharm Sin B. 2021 Dec;11(12):3966-3982. Acta Pharmacol Sin. 2022 Oct 25. Autophagy. 2022 Oct 27. Biochem Pharmacol. 2021 Dec 28;114904. BMC Med. 2021 Oct 15;19(1):247. Cell Death Dis. 2020 Apr 24;11(4):279. Cell Discov. 2020 Mar 18;6:16. Cell Rep. 2021 Apr 6;35(1):108959. Cell Signal. 2019 Feb;54:17-26. Clin Chem. 2019 Dec;65(12):1522-1531. Clin Sci (Lond). 2019 Aug 14;133(15):1759-1777. Eur J Pharmacol. 2 September 2022, 175237. Front Bioeng Biotechnol. 2020 May 8;8:378. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep. Heliyon. 2023 Oct 31. iScience. 30 June 2022, 104690. J Autoimmun. 2019 May;99:39-47. J Biol Chem. 2023 May 11;104814. J Control Release. 2020 Jan 28;320:304-313. Life Sci. 2020 Apr 1;246:117366. Life Sci. 2020 Feb 15;243:117277. Life Sci. 2021 Oct 26;120095. Nat Biomed Eng. 2021 Nov 8. Nat Commun. 2021 Aug 16;12(1):4964. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. Pharmacol Res. 2021 Apr 30;169:105642. Phytomedicine. 2021, 153465. Research Square Preprint. 2021 Oct. Sci Rep. 2022 Oct 29;12(1):18259. STAR Protoc. 2022, 3(4): 101859. Theranostics. 2020 Apr 27;10(13):5829-5844. Acta Pharmacol Sin. 2021 Feb 19. Aging. 2021 Mar 10;13(6):8421-8439. Am J Cancer Res. 2020 Nov 1;10(11):3896-3910. Arthritis Rheumatol. 2022 Sep 3. Autophagy. 2021 Sep 15;1-19. Autophagy. 2022 Aug 29. Autophagy. 2022 Jan 6;1-20. Biochem Biophys Res Commun. 2 March 2022. Biochem Biophys Res Commun. 2020 Dec 10;533(3):474-480. Br J Pharmacol. 2023 Feb 14. Cell Biochem Funct. 2022 Apr 29. Curr Med. 2023 Oct 17. iScience. 30 June 2022, 104690. J Exp Pharmacol. 2022 Nov 8;14:353-365 Nat Biotechnol. 2022 Dec;40(12):1834-1844. Nat Commun. 2022 Jun 14;13(1):3419. Patent. US20230218606A1. Research Square Preprint. 2023 Sep 6. Virology. 2023 Jul 24. [1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.
Smiles	CCN(CCO)CCCC(NC1=CC=NC2=CC(Cl)=CC=C12)C.O=S(O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HCQ (sulfate)
Available
Product Description	Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	433.95
Clinical Information	Launched
Solubility	DMF : 1.4 mg/mL (ultrasonic)\|DMSO : < 1 mg/mL (ultrasonic)\|H2O : 110 mg/mL (ultrasonic; warming)
Isoform	Plasmodium; TLR7; TLR9
Pathway	Anti-infection; Autophagy; Immunology/Inflammation
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-B1370-50mg-safety-datasheet.pdf