WT-161

€104.00

Excl. VAT

Item no.	HY-100871-10mM
Manufacturer	MedChem Express
CASRN	1206731-57-8
Amount	10 mM/1 mL
Category	Oncology Neuroscience Aging & Neurological Disorders Neural Epigenetics Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer Lymphatic System Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	98.36
Formula	C27H30N4O3
Citations	[1]Hideshima T, et al. Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13162-13167. [2]Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.
Smiles	O=C(N/N=C/C1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1)CCCCCCC(NO)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1206731-57-8
Available
Product Description	WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM[1]. WT-161 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2)[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	458.55
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 100 mg/mL
Isoform	HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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HY-100871-10mM-safety-datasheet.pdf