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Recombinant Human CD40 ligand(CD40LG),partial (Active)

Recombinant Human CD40 ligand(CD40LG),partial (Active)

€156.00

Excl. VAT

Item no.	CSB-AP002211HU-10
Manufacturer	Cusabio
Amount	10ug
Category	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Host	E.coli
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD40-L, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD antigen CD154
Available
Classification	Cytokine
Subdivision	Tumor Necrosis Factor
Research Areas	Cancer
Uniprot NO.	P29965
Uniprot Entry Name	CD40L_HUMAN
Gene Names	CD40LG, CD40L, TNFSF5, TRAP
Source	E.Coli
Expression Region	113-261aa
Sequence	MQKGDQNPQI AAHVISEASS KTTSVLQWAE KG YYTMSNNL VTLENGKQLT VKRQGLYYIY AQVT FCSNRE ASSQAPFIAS LWLKSPGRFE RILLRA ANTH SSAKPCGQQS IHLGGVFELQ PGASVFVN VT DPSQVSHGTG FTSFGLLKL
Protein Description	Partial
Tag Info	Tag-Free
Mol. Weight	16.3 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 5-10 ng/ml.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.0 , lyophilized
Alias	CD40-L, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD antigen CD154
Relevance	Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269\|PubMed:15193700}.; Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269\|PubMed:15193700}.
PubMed ID	1280226; 1385114; 7678782; 1281209; 7678552; 7999797; 15489334; 8626375; 11676606; 15193700; 8589998; 9605317; 7679206; 8094231; 7679801; 7717401; 7532185; 8889581; 8550833; 9150729; 9746782
Function	Cytokine that binds to CD40/TNFRSF5
Involvement in disease	Immunodeficiency with hyper-IgM, type 1 (HIGM1)
Subcellular Location	Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted
Protein Families	Tumor necrosis factor family
Tissue Specificity	Specifically expressed on activated CD4+ T-lymphocytes.
Paythway	NF-kappaBsignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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