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Recombinant Human CD40 ligand(CD40LG),partial (Active)

Recombinant Human CD40 ligand(CD40LG),partial (Active)

156,00 €

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ArtNr	CSB-AP002211HU-10
Hersteller	Cusabio
Menge	10ug
Kategorie	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Host	E.coli
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD40-L, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD antigen CD154
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Classification	Cytokine
Subdivision	Tumor Necrosis Factor
Research Areas	Cancer
Uniprot NO.	P29965
Uniprot Entry Name	CD40L_HUMAN
Gene Names	CD40LG, CD40L, TNFSF5, TRAP
Source	E.Coli
Expression Region	113-261aa
Sequence	MQKGDQNPQI AAHVISEASS KTTSVLQWAE KG YYTMSNNL VTLENGKQLT VKRQGLYYIY AQVT FCSNRE ASSQAPFIAS LWLKSPGRFE RILLRA ANTH SSAKPCGQQS IHLGGVFELQ PGASVFVN VT DPSQVSHGTG FTSFGLLKL
Protein Description	Partial
Tag Info	Tag-Free
Mol. Weight	16.3 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 5-10 ng/ml.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.0 , lyophilized
Alias	CD40-L, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD antigen CD154
Relevance	Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. {ECO:0000269\|PubMed:15193700}.; Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269\|PubMed:15193700}.
PubMed ID	1280226; 1385114; 7678782; 1281209; 7678552; 7999797; 15489334; 8626375; 11676606; 15193700; 8589998; 9605317; 7679206; 8094231; 7679801; 7717401; 7532185; 8889581; 8550833; 9150729; 9746782
Function	Cytokine that binds to CD40/TNFRSF5
Involvement in disease	Immunodeficiency with hyper-IgM, type 1 (HIGM1)
Subcellular Location	Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted
Protein Families	Tumor necrosis factor family
Tissue Specificity	Specifically expressed on activated CD4+ T-lymphocytes.
Paythway	NF-kappaBsignalingpathway

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