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Recombinant Human Galectin-3 protein(LGALS3) (Active)

Recombinant Human Galectin-3 protein(LGALS3) (Active)

€972.00

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Item no.	CSB-AP000481HU-500
Manufacturer	Cusabio
Amount	500ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Others
Subdivision	Others
Research Areas	Neuroscience
Uniprot NO.	P17931
Uniprot Entry Name	LEG3_HUMAN
Gene Names	LGALS3, MAC2
Source	E.Coli
Expression Region	2-250aa
Sequence	ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GA GGYPGASY PGAYPGQAPP GAYPGQAPPG AYPG APGAYP GAPAPGVYPG PPSGPGAYPS SGQPSA TGAY PATGPYGAPA GPLIVPYNLP LPGGVVPR ML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP F ESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHR VKKLNEI SKLGISGDID LTSASYTMI
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	26.0 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by its ability to agglutinate human red blood cells is less than 10 ug/ml.
Purity	>98% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 20 mM PB, pH 7.4, 150mM NaCl , lyophilized
Alias	Gal-3, Carbohydrate-binding protein 35, CBP 35, Galactose-specific lectin 3, Galactoside-binding protein
Relevance	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. {ECO:0000250, ECO:0000269\|PubMed:15181153, ECO:0000269\|PubMed:19594635, ECO:0000269\|PubMed:19616076}.
PubMed ID	2261464; 2402511; 2022338; 2009535; 7682704; 9439577; 14702039; 12508121; 15489334; 8253806; 9501082; 15181153; 19594635; 19497882; 19616076; 21269460; 9582341
Function	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus
Subcellular Location	Cytoplasm, Nucleus, Secreted
Tissue Specificity	A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500ug

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