Recombinant Human Galectin-3 protein(LGALS3) (Active)

Others

P17931

LGALS3, MAC2

2-250aa

Full Length of Mature Protein

26.0 kDa

>98% as determined by SDS-PAGE and HPLC.

0.2 um filtered 20 mM PB, pH 7.4, 150mM NaCl , lyophilized

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076}.

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.