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PLX7904

PLX7904

€1,350.00

Excl. VAT

Item no.	M9008-50mg
Manufacturer	AbMole
Amount	50mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Cas #	1393465-84-3
Bioactivity information	PLX7904 is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAF^V600E in mutant RAS expressing cells. PLX7904 potently inhibit ERK1/2-driven GAL4-Elk1 reporter activity in PRT cells as well as parental cells. PLX7904 potently inhibits phosphorylation of ERK1/2 in mutant BRAF melanoma cells without eliciting paradoxical activation in wild-type BRAF, mutant NRAS melanoma cells. In vivo, PLX7904 inhibits the COLO205 xenograft growth in eight mice per group.
Target	Raf
Synonyms	PB04
MW	512, 53
Formula	C24H22F2N6O3S
Solubility	DMSO: >= 40 mg/mL
Purity	>98%

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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M9008-50mg-safety-datasheet.pdf