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GSK1059615

GSK1059615

€140.00

Excl. VAT

Item no.	M1978-10mg
Manufacturer	AbMole
Amount	10mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Hepatic Cancer
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Similar products	GSK1059615
Available
Cas #	958852-01-2
Bioactivity information	GSK1059615 is a potent, ATP-competitive inhibitor of PI 3-kinase alpha (PI3Kalpha) with IC50 of 2 nM. Phosphatidylinositol-3 kinases (PI3K) are critical for malignant cellular processes including growth, proliferation, and survival. GSK1059615 is also a novel inhibitor of PI3Kbeta, PI3Kdelta, PI3Kgamma and mTOR with IC50 of 0.6 nM, 2 nM, 5 nM and 12 nM, respectively. GSK1059615 (25 mg/kg) effectively inhibits tumor growth in xenograft mice models of BT474 or HCC1954 breast cancer cells and attenuates MAPK signaling.
Target	PI3K
MW	333, 36
Formula	C18H11N3O2S
Solubility	DMSO
Purity	>98%

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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M1978-10mg-safety-datasheet.pdf