Anti-KIR2DS4 Antibody

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

KIR2DS4 antibody
Killer cell immunoglobulin-like receptor 2DS4 antibody
CD158 antigen-like family member I antibody
MHC class I NK cell receptor antibody
Natural killer-associated transcript 8 antibody
NKAT-8 antibody
P58 natural killer cell receptor clones CL-39/CL-17 antibody
p58 NK receptor CL-39/CL-17 antibody
CD antigen CD158i antibody
KIR2DS4 antibody
CD158I antibody
KKA3 antibody
NKAT8 antibody

Unconjugated

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

KIR2DS4

IgG

For Research Use Only (RUO).

Store at -20C. Avoid freeze / thaw cycles.

P43632