Recombinant Mouse B7-H5/Gi24/VISTA Protein

VSIR, V-Set Immunoregulatory Receptor, also known as VISTA, is an immunoregulatory receptor that inhibits the T-cell response. It may promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. VSIR, or V-set immunoregulatory receptor, could be involved in the pathogenesis of chronic rhinosinusitis with nasal polyps. V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4+ and CD8+ T cell activation when expressed on antigen-presenting cells. VSIR is broadly expressed in the spleen, bone marrow, and other tissues. Diseases associated with VSIR include Ichthyosis, Congenital, Autosomal Recessive 6, and Monckeberg Arteriosclerosis.

Proteins

Phe33-Ala191

Other Recombinant Protein

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Measured by its binding ability in a functional ELISA.Immobilized Mouse B7-H5/VISTA (Catalog: RP01328) at 0.5 μg/mL (100 μL/well) can bind B7-H5/VISTA Rabbit pAb with a linear range of 0.01-2.6 ng/mL.