Recombinant Mouse CTLA-4/CD152 Protein

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family, and is similar to the T-cell co-stimulatory protein, CD28, both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal.Intracellular CTLA4 is also found in regulatory T cells, CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy.

Proteins

Glu36-Asp161

Immune Checkpoint, Bio-Markers & CD Antigens

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Measured by its binding ability in a functional ELISA. Immobilized Mouse CTLA-4/CD152 at 2μg/mL (100μL/well) can bind Mouse B7-2/CD86 with a linear range of 0.1-51.8 ng/mL.