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Recombinant Cynomolgus TIM-3/HAVCR2 Protein

Recombinant Cynomolgus TIM-3/HAVCR2 Protein

195,00 €

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ArtNr	RP00776-50ug
Hersteller	Abclonal
Menge	50 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	Monkey (Cynomolgus, Simian)
Purity	> 95% by SDS-PAGE.
Sequence	SEVEYIAEVGQNAYLPCSYTPAPPGNLVPVCWGKGACPVFDCSNVVLRTDNRDVNDRTSGRYWLKGDFHKGDVSLTIENVTLADSGVYCCRIQIPGIMNDEKHNVKLVVIKPAKVTPAPTLQRDLTSAFPRMLTTGEHGPAETQTPGSLPDVNLTVSNFFCELQIFTLTNELRDSGATIR
NCBI	Cynomolgus TIM-3/HAVCR2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	T cell immunoglobulin and mucin domain3; HAVCR2; Tim-3; TIM3
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Description	Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Background	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules.Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembranesegment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells(macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding toGalectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg andmyeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Route	C-Fc
Manufacturers Category	Proteins
Endotoxin	< 1 EU/μg of the protein by LAL method.
Immunogen	Ser22-Arg201
Storage	Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Manufacturers Research Area	Immune Checkpoint
Gene Symbol	Cynomolgus TIM-3/HAVCR2
Protein Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.
Protein Description	Recombinant Cynomolgus TIM-3/HAVCR2 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Ser22-Arg201) of cynomolgus TIM-3/HAVCR2 (Accession #G7P6Q7) fused with an Fc tag at the C-terminus.

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Menge: 50 ug

Listenpreis: 195,00 €

Preis: 195,00 €

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Lieferung vsl. bis 30.09.2025

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