Recombinant Mouse VISTA/B7-H5/Gi24 Protein

Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immunecostimulatory molecules. Mature mouse Gi24 contains a 159 amino acid (aa) extracellular domain (ECD) withone V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotesboth MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiationof embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulatedfollowing BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor ActivinRIB/ALK-4. It is expressed on the surface of naïve CD4+ T cells and regulatory T cells. It is up-regulated in vivoon activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and theirproduction of IL-2 and IFN- γ . Its expression on tumor cells attenuates the antitumor immune response andenables more rapid tumor progression.

Proteins

Phe33-Ala191

Immune Checkpoint

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.