Recombinant Marmoset TIM-3/HAVCR2 Protein

T cell immunoglobulin and mucin domain-3 (TIM3, HAVCR2), is a transmembrane glycoprotein of the TIMfamily of immune regulating molecules and plays an important role in the Th1-mediated immune response.TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement ofTIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immunetolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotesinflammation through the activation of innate immune cells. TIM3 is also regarded as a potential targetmolecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitoryregulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated withchronic HBV infection including HBV-related HCC.

Proteins

Glu24-Ile193

Immune Checkpoint

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.