Recombinant Human c-kit/CD117/Mast/stem Cell Growth Factor Receptor Kit Protein

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cellfactor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongsto the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enablesthem to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immunesuppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing stimuli, and it is required forsubsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cellsfrom apoptosis and assists in the recovery of cardiac function following myocardial infarction.

Proteins

Gln26-Thr520

Bio-Markers & CD Antigens

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.

Measured by its ability to inhibit SCF-dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 2-6 μg/mL in the presence of 8 ng/mL of recombinant human CD117.