Marimastat

155,00 €

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ArtNr	HY-12169-10mg
Hersteller	MedChem Express
CAS-Nr.	154039-60-8
Menge	10 mg
Kategorie	Oncology Neuroscience Neuroinflammation Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Typ	Inhibitors
Specific against	other
Purity	98.0
Formula	C15H29N3O5
Citations	[1]Yu M, et al. Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity. ChemistryOpen. 2013 Jun;2(3):99-105. [2]van Wijngaarden J, et al. An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510. Biochem Biophys Res Commun. 2010 Jan 8;391(2):1161-5. [3]Rasmussen HS, et al. Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol Ther. 1997;75(1):69-75. [4]Skipper JB, et al. In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts. ORL J Otorhinolaryngol Relat Spec. 2009;71(1):1-5.
Smiles	O=C(NO)[C@@H](O)[C@@H](CC(C)C)C(N[C@H](C(NC)=O)C(C)(C)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BB2516; TA2516
Lieferbar
Product Description	Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs, with potent activity against MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM) and MMP-7 (IC50=13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	331.41
Clinical Information	Phase 3
Solubility	DMSO : 100 mg/mL (ultrasonic)
Isoform	MMP-1; MMP-14; MMP-2; MMP-3; MMP-7
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-12169-10mg-safety-datasheet.pdf