IFT57 Polyclonal Antibody

CDNA FLJ10147 fis clone HEMBA1003369, Dermal papilla derived protein 8, Dermal papilla-derived protein 8, DERP 8, DERP8, Esrrbl 1, Esrrbl1, ESRRBL1 protein, Estrogen related receptor beta like 1, Estrogen related receptor beta like protein 1, Estrogen-related receptor beta-like protein 1, FLJ10147, Hip1 Interacting protein, HIP1 interacting protein HIPPI, Hip1 protein interactor, HIP1-interacting protein, HIPPI, Huntingtin interacting protein 1 interacting protein, Huntingtin interacting protein 1 protein interactor, IFT 57, ift57, IFT57, Intraflagellar transport 57 homolog (Chlamydomonas), Intraflagellar transport 57 homolog, Intraflagellar transport protein 57 homolog, MHS4R2, Vestrogen related receptor beta like 1

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

IHC 1:50-1:300, ELISA 1:5000-1:10000

BC011899