Recombinant Mouse CD86/B7-2 Protein

CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. CD86 is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response.

Proteins

Val24-Glu245

Immune Checkpoint, Bio-Markers & CD Antigens

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.

1.Measured by its binding ability in a functional ELISA. Immobilized Mouse CTLA-4/CD152 at 2 μg/mL (100 μL/well) can bind Mouse B7-2/CD86 with a linear range of 0.1-54.9 ng/mL.