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PE Anti-Mouse Ly-6G (Gr-1) (RB6-8C5)

PE Anti-Mouse Ly-6G (Gr-1) (RB6-8C5)

€28.00

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Item no.	50-5931-U025
Manufacturer	Tonbo Biosciences
Amount	25 ug
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	PE
Applications	FC
Clone	RB6-8C5
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b kappa
Conjugate/Tag	PE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Gr1, Ly6G
Similar products	Gr-1
Available
Description	The RB6-8C5 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils. In the mouse, the RB6-8C5 antibody is typically used in combination with the macrophage labeling antibody M1/70 (Anti-CD11b) for phenotypic analysis of monocytes, macrophages and granulocytes. Note: The RB6-8C5 antibody has been reported to cross-react with Ly-6C on cells expressing this antigen (Fleming et al. 1993. J. Immunol. 151:2399-2408 and Sasmono et al. 2007. J. Leukoc. Biol. 82: 111-123) and has been cited in the literature for identification of Ly-6G/Ly-6C. Other reports suggest that this antibody is specific for Ly-6G, without cross-reactivity for Ly-6C (Nagendra S. and Schlueter AJ. 2003. Cytometry A, 58(2): 195-200.
Alternative Names	Gr1, Ly6G
Gene ID	17067
Citations	Berent-Maoz B, Montecino-Rodriguez E, Signer RAJ, and Dorshkind K. 2012. Blood. 199:5715-5721. (Flow cytometry) von Bruhl M-L, Stark K, Steinhart A, et al. 2012. J. Exp. Med. 209: 819-835. (Intravital fluorescent microscopy - video) Le HT, Tran VG, Kim W, Kim H, Cho HR, and Kwon B. 2012. J. Immunol. 189:287-295. (in vivo neutrophil depletion) Doring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, and Zernecke A. 2012. Arterioscler. Thromb. Vasc. Biol. 32: 1613-1623. (in vivo depletion) Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, and Yewdell JW. 2011. J. Exp. Med. 208: 2511-2524. (Immunohistochemistry - OCT embedded frozen tissue) Wang T, Tian L, Haino M, Gao J-L, Lake R, Ward Y, Wang H, Siebenlist U, Murphy PM, and Kelly K. 2007. Infect. Immun. 75(3):1144-1153. (Immunohistochemistry - zinc fixed tissue) Nutt SL, Metcalf D, D´ Amico A, Polli M, and Wu L. 2005. J. Exp. Med. 201:221-231. (Immunomagnetic bead depletion) Whiteland JL, Nicholls SM, Shimeld C, Easty DL, Williams NA, and Hill TJ. 1995. J. Histochem. Cytochem. 43:313-320. (Immunohistochemistry - frozen tissue, paraffin embedded tissue) Fleming TJ, Fleming ML, and Malek TR. 1993. J. Immunol. 151:2399-2408. (in vitro blocking, immunoprecipitation)

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Amount: 25 ug

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