« Back
Home /
FITC Anti-Mouse CD62L (L-Selectin) (MEL-14)

FITC Anti-Mouse CD62L (L-Selectin) (MEL-14)

€61.00

Excl. VAT

Item no.	35-0621-U100
Manufacturer	Tonbo Biosciences
Amount	100 ug
Category	Neuroscience Neural Lineage Markers Neural Signaling Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	FITC
Applications	FC
Clone	MEL-14
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2a kappa
Conjugate/Tag	FITC
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	LECAM-1, Ly-22
Similar products	L-Selectin
Available
Description	The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte " rolling" on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research. The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature. Recent Publications: Fenutria R, Martinez VG, Simoes I, Postigo J, Gil V, Martinez-Florensa M, Sintes J, Naves R, Cashman K, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P and Lozano F. 2014. PloS One. 9:e84895. (Flow Cytometry) Pannu J, Belle JI, Forster M, Duerr CU, Shen S, Kane L, Harcourt K, Fritz JH, Clare S and Nijnik A. 2015. PloS one. DOI: 10.1371/journal.pone.0117304. (Flow Cytometry)
Alternative Names	LECAM-1, Ly-22
Gene ID	20343
Citations	Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry). Harp JR, Gilchrist MA, and Onami TM. 2010. J. Immunol. 185:5751-5761. (in vivo blocking) Furukawa Y, Umemoto E, Jang MH, Tohya K, Miyasaka M, and Hirata T. 2008. J. Biol. Chem. 283: 12112-12119. (Immunoelectron microscopy) Li Y, Brazzell J, Herrera A, and Walcheck B. 2006. 108: 2275-2279. (Immunoprecipitation) Ochando JC, Yopp AC, Yng Y, Garin A, Li Y, Boros P, Llodra J, Ding Y, Lira SA, Krieger NR, and Bromberg JS. 2005. J. Immunol. 174: 6993-7005. (in vivo blocking, Flow cytometry) Zhao L-C, Shey M, Farnsworth M, and Dailey MO. 2001. J. Biol. Chem. 276: 30631-30640. (Immunoprecipitation) Suzuki A, Andrew DP, Gonzalo JA, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher EC, Suda T, Gutierrez-Ramos JC, and Mak TK. 1996. Blood. 87:3550-3562. (Stamper-Woodruff assay; in vivo blocking) Reichert RA, Jerabek L, Gallatin WM, Butcher EC, and Weissman IL. 1986. 136(10): 3535-3542. (Immunohistochemistry) Specific References: Fenutria R, Martinez VG, Simoes I, Postigo J, Gil V, Martinez-Florensa M, Sintes J, Naves R, Cashman K, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P and Lozano F. 2014. PloS One. 9:e84895. (Flow Cytometry)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

35-0621-U100-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 100 ug

Listprice: €61.00

Price: €61.00

available

Delivery expected until 9/11/2025

Quantity:

Compare