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The DATK32 antibody is specific for a combinatorial epitope of the mouse integrin alpha 4/beta 7 (LPAM-1) heterodimer. LPAM-1 is expressed on most mature lymphocytes and sub-populations of thymocytes and bone marrow cells. It is involved in lymphocyte adhesion and migration and is a receptor for several extracellular matrix proteins including VCAM-1, fibronectin, and MAdCAM-1.
DATK32 is reported to induce LPAM-1 dependent lymphocyte aggregation and block adhesion to VCAM-1, fibronectin, and MAdCAM-1.
Andrew DP, Berlin C, Honda S, et al. 1994. J Immunol. 153(9):3847-3861.
Berlin C, Berg EL, Briskin MJ, et al. 1993. Cell. 74(1):185-195.
Bogetto L, Gabriele E, Cariati R, et al. 2000. Blood. 95:2397-2406.
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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