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APC Anti-Mouse CD86 (B7-2) (GL-1)

APC Anti-Mouse CD86 (B7-2) (GL-1)

€50.00

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Item no.	20-0862-U025
Manufacturer	Tonbo Biosciences
Amount	25 ug
Category	Neuroscience Neural Lineage Markers Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	APC
Applications	FC
Clone	GL-1 (GL1)
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2a kappa
Conjugate/Tag	APC
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	B7.2, B70, Ly-58
Similar products	B7-2
Available
Description	The GL-1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The GL-1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.
Alternative Names	B7.2, B70, Ly-58
Gene ID	12524
Citations	Liu Z, Geboes K, Hellings P, Maerten P, Heremans H, Vandenberghe P, Boon L, van Kooten P, Rutgeerts P, and Ceuppens JL. 2011. J. Immunol. 167: 1830-1838. (in vivo blocking, Immunohistochemistry - OCT embedded frozen tissue) Kastenmuller W, Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, and Germain RN, 2011. J. Immunol. 187: 3186-3197. (in vivo blocking) Zheng SG, Wang JH, Stohl, W, Kim KS, Gray JD, and Horwitz DA. 2006. J. Immunol. 176:3321-3329. (in vitro blocking) Leithauser F, Meinhardt-Krajina T, Fink K, Wotschke B, Moller P and Reimann J. 2006. Am. J. Pathol. 168(6): 1898-1909. (Immunohistochemistry - frozen tissue) Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, and Holdsworth SR. 2005. J. Am. Soc. Nephrol. 16: 2012-2022. (in vivo activation, Immunofluorescence microscopy - frozen tissue, Immunohistochemistry - frozen tissue) Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, and Bluestone JA. 1995. J. Exp. Med. 181:1145-155. (in vitro blocking) Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Gray GS, and Vallera DA. 1995. Blood. 85: 2607-2618. (Immunohistochemistry - OCT embedded frozen tissue)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 ug

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Delivery expected until 9/11/2025

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