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PE-Cyanine5 Anti-Human/Mouse CD44 (IM7)

PE-Cyanine5 Anti-Human/Mouse CD44 (IM7)

€98.00

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Item no.	55-0441-U100
Manufacturer	Tonbo Biosciences
Amount	100 ug
Category	Oncology Antibodies By Cell Type Carcinoma Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies By Organ Bladder Cancer Colorectal Cancer Breast Cancer Head & Neck Cancer Testicular & Prostate Cancer Gastric Cancer
Type	Antibody Monoclonal
Format	PE-Cy5
Applications	FC
Clone	IM7
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b kappa
Conjugate/Tag	PE/Cy5
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Pgp-1, MDU3, Hermes, Hyaluronate receptor
Similar products	IM7
Available
Description	The IM7 antibody recognizes CD44, a ubiquitously expressed cell surface receptor which is important for extracellular matrix organization, cell-cell and cell-matrix adhesion and migration. CD44 may be expressed in a number of different isoforms (splice variants) from the most typical or " standard" form, known as CD44s, to variants designated CD44v, e.g. CD44v1 or CD44v6. These receptors interact with several ligands, but most often associate with an extracellular matrix component hyaluronate, through which it mediates adhesion. The IM7 antibody may be used for detection of all isoforms of CD44, as it recognizes constant epitopes near the extracellular proximal domain. (Xu et al, 2002, J. Leukoc. Biol. 72:1133-1141). It has been reported to be cross-reactive with many non-human species including Baboon, Chimpanzee, Cynomolgus, Rhesus, Horse, Cow, Pig, Dog and Cat CD44.
Alternative Names	Pgp-1, MDU3, Hermes, Hyaluronate receptor
Gene ID	12505
Citations	Chandler HL, Haeussler DJ, Gemensky-Metzler AJ, Wilkie DA, and Lutz EA. 2012. Invest. Ophthalmol. Vis. Sci. 53:1835-1845. (in vitro blocking, canine) Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry). Ruffell B, Poon GFT, Lee SSM, Brown KL, Tjew S-L, Cooper J, and Johnson P. 2011. J. Biol. Chem. 286:19179-19190. (Immunoprecipitation) Miyake Y, Matsumoto H, Yokoo M, Miyazawa K et al. 2006. Biol. Reprod. 74: 501-510. (Immunohistochemistry - frozen tissue, swine) Veir JK, Lappin MR, and Dow SW. 2006. Journal of Feline Medicine and Surgery. 8:400-411. (Flow cytometry - feline) Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, and Frank MH. 2005. Cancer Res. 65:4320-4333. (Immunohistochemistry - frozen tissue) Fischer A, Schumacher N, Maier M, Sendtner M, and Gessler M. 2004. Genes & Dev. 18:901-911. (Immunohistochemistry - paraffin embedded tissue) Xu H, Manivannan A, Liversidge J, Sharp PF, Forrester JV, and Crane IJ. 2002. J. Leukoc. Biol. 72:1133-1141. (in vivo functional assays, induction of apoptosis) Si-Tahar M, Sitaraman S, Shibahara T, and Madara JL. 2001. Am. J. Physiol. Cell Physiol. 280:C423-C432. (in vitro functional assays, Western Blot)
Cross Reactivity	Baboon, Canine, Chimpanzee, Cynomolgus, Equine, Feline, Rhesus, Swine

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 8/28/2025

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