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The 15.2 antibody reacts with human CD54, also known as ICAM-1 (Intercellular Adhesion Molecule 1), a 90-110 kDa cell surface glycoprotein that is inducibly expressed on both immune and endothelial cells. As its name implies, ICAM-1 participates in cell-cell adhesion between leukocytes and endothelial cells, facilitating leukocyte recruitment and transmigration at sites of inflammation. The ligands for ICAM-1 are also expressed on leukocyte and endothelial cells, and include Mac-1, fibrinogen, and a member of the integrin protein family, LFA-1 (CD11a).
The 15.2 antibody may be used for analysis of ICAM-1 expression in human cells and tissues, and is reported to be cross-reactive with porcine ICAM-1.
Sommaggio R, Cohnen A, Watzl C, and Costa C. 2012. J. Immunol. 188: 2075-2083. (in vitro blocking - Pig)
Avril M, Tripathi AK, Brazier AJ, Andisi C, Janes JH, Soma VL, Sullivan DJ, Bull PC, Stins MF, and Smith JD. 2012. Proc. Natl. Acad. Sci. 109: E1782-E1790. (in vitro blocking)
Dryden NH, Sperone A, Martin-Almedina S, Hannah RL, Birdsey GM, Khan ST, Layhadi JA et al. 2012. J. Biol. Chem. 287: 12331-12342. (Western Blot)
Di Lorenzo A, Manes TD, Davalos A, Wright PL, and Sessa WC. 2011. Blood. 117: 2284-2295. (in vitro activation/cross-linking)
Kim S, and Nadel JA. 2009. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L174-L183. (in vitro blocking, Western Blot)
Goto E, Kohrogi H, Hirata N, Tsumori K, Hirosako S, Hamamoto J, Fujii K, Kawano O, and Ando M. 2000. Am. J. Respir. Cell Mol. Biol. 22: 405-411. (Immunohistochemistry - frozen tissue)
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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