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Setipiprant

Setipiprant

€30.00

Excl. VAT

Item no.	TMO-T3520-5mg
Manufacturer	TargetMol
CASRN	866460-33-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Diamant Z., et al. Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics. Clin Exp Allergy. 2014 Aug;44(8):1044-52.
Smiles	C1CN(CC2=C1N(C3=C2C=C(C=C3)F)CC(=O)O)C(=O)C4=CC=CC5=CC=CC=C54
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	GPR antagonist, ACT-129968 , KYTH-105
Available
Short Description	Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.
Shipping	cool pack
Storage	-20°
Target names or alias	ACT-129968 , KYTH-105
Molecular Weight	402, 42
Pathway	Immunology/Inflammation\|\|\|Endocrinology/Hormones\|\|\|GPCR/G Protein
Target	Prostaglandin Receptor\|\|\|GPR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

Listprice: €30.00

Price: €30.00

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Delivery expected until 8/21/2025

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