Anti-FAS-L antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

FAS-L is a protein encoded by the FASLG gene which is approximately 31, 4 kDa. FAS-L is localised to the cell membrane and is involved in PEDF induced signalling, dimerization of procaspase-8, apoptosis modulation and signalling and the TNFR1 pathway. FAS-L is a member of the tumor necrosis factor superfamily. It is a cytokine that binds to TNFRSF6/FAS which is a receptor that transduces the apoptotic signal into cells. It may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. FAS-L is expressed in the blood, spleen, lymph nodes, intestine and kidney. Mutations in the FASLG gene result in autoimmune lymphoproliferative syndrome 1B. STJ93042 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FAS-L protein.

FASLG

70-150 aa, Internal

Cell membrane Cytoplasmic vesicle lumen Lysosome lumen. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane. Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted. May be released into the extracellular fluid by cleavage from the cell surface. FasL intracellular domain: Nucleus. The FasL ICD cytoplasmic form is translocated into the nucleus.

WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:40000

Tumor necrosis factor ligand superfamily member 6
Apoptosis antigen ligand
APTL
CD95 ligand
CD95-L
Fas antigen ligand
Fas ligand
FasL
CD antigen CD178
Tumor necrosis factor ligand superfamily member 6

P48023_HUMAN