Anti-PEX5 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P50542

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

PEX5

Rabbit polyclonal against PEX5

Cytoplasm
Peroxisome Membrane
Peripheral Membrane Protein
Its Distribution Appears To Be Dynamic
It Is Probably A Cycling Receptor Found Mainly In The Cytoplasm And As Well Associated To The Peroxisomal Membrane Through A Docking Factor (Pex13)

WB 1:500-1:2000

Peroxisomal Targeting Signal 1 Receptor
Pts1 Receptor
Pts1r
Pts1-Bp
Peroxin-5
Peroxisomal C-Terminal Targeting Signal Import Receptor
Peroxisome Receptor 1

PEX5_HUMAN