Anti-ATG5 antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

ATG5 is a protein encoded by the ATG5 gene which is approximately 32, 4 kDa. ATG5 is localised to the cytoplasm. It is involved in the autophagy pathway, longevity regulating pathway, the innate immune system and pink/parkin mediated mitophagy. It functions as an E1-like activating enzyme, in combination with autophagy protein 12, in a ubiquitin-like conjugating system. It is involved in multiple cellular processes such as mitochondrial quality control after oxidative damage, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. ATG5 is expressed ubiquitously in human tissues and mutations in the ATG5 gene may result in Bardet-Biedl syndrome. STJ98903 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous ATG5 protein.

ATG5

Mouse monoclonal against ATG5

Cytoplasm. Preautophagosomal structure membrane. Peripheral membrane protein. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.

IF 1:50-200
WB 1:500-2000
IHC-p 1:50-300

Autophagy protein 5
APG5-like
Apoptosis-specific protein

Q9H1Y0_HUMAN