Anti-TNF-Alpha antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

TNF-alpha is a protein encoded by the TNF gene which is approximately 25, 6 kDa. TNF-alpha is localised to the cell membrane. It is involved in PEDF induced signalling, TNFR1 pathway, allograft rejection and apoptosis modulation and signalling. It is a cytokine that is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, lipid metabolism, and coagulation. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-alpha is expressed in the blood, lung, spleen, liver and heart. Mutations in the TNF gene may result in psoriatic arthritis. STJ96054 was affinity purified. This polyclonal antibody binds to endogenous TNF-alpha.

TNF

110-190 aa, Internal

Cell Membrane
Single-Pass Type Ii Membrane Protein
Tumor Necrosis Factor
Membrane Form: Membrane
Soluble Form: Secreted
C-Domain 1: Secreted
C-Domain 2: Secreted

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000

Tumor Necrosis Factor
Cachectin
Tnf-Alpha
Tumor Necrosis Factor Ligand Superfamily Member 2
Tnf-A [Cleaved Into-Tumor Necrosis Factor-Membrane Form
N-Terminal Fragment
Ntf-Intracellular Domain 1
Icd1-Intracellular Domain 2
Icd2-C-Domain 1-C-Domain 2-Tumor Necrosis Factor-Soluble Form]

TNFA_HUMAN