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Anti-Kv2.1 antibody

Anti-Kv2.1 antibody

€121.00

Excl. VAT

Item no.	STJ93873-50
Manufacturer	St John's Laboratory
Amount	50ul
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies Immunohistochemistry ELISA Immunofluorescence Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies
Type	Antibody Polyclonal
Applications	IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Anti-Potassium Voltage-Gated Channel Subfamily B Member 1 antibody</br>Anti-Delayed Rectifier Potassium Channel 1 antibody</br>Anti-Drk1 antibody</br>Anti-H-Drk1 antibody</br>Anti-Voltage-Gated Potassium Channel Subunit Kv2.1 antibody</br>Anti-KCNB1 antib
Similar products	Anti-Potassium Voltage-Gated Channel Subfamily B Member 1 antibody Anti-Delayed Rectifier Potassium Channel 1 antibody Anti-Drk1 antibody Anti-H-Drk1 antibody Anti-Voltage-Gated Potassium Channel Subunit Kv2.1 antibody Anti-KCNB1 antib
Available
Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Uniprot ID	Q14721
Storage	Store at-20° C, and avoid repeat freeze-thaw cycles.
Concentration	1 mg/ml
Description	Kv2.1 is a protein encoded by the KCNB1 gene which is approximately 95, 8 kDa. Kv2.1 is localised to the cell membrane. It is involved in integration of energy metabolism, potassium channels and aquaporin-mediated transport. It contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and also plays a role in homeostatic attenuation of electrical excitability throughout the brain. Kv2.1 is expressed in the brain, heart, lung, liver, colon, kidney and adrenal gland. Mutations in the KCNB1 gene may result in epileptic encephalopathy. STJ93873 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Kv2.1 protein.
Gene ID	3745
Gene symbol	KCNB1
Immunogen	Synthesized peptide derived from human Kv2.1 around the non-phosphorylation site of S567.
Immunogen region	510-590 aa
Short Description	Rabbit polyclonal against Kv2.1
Tissue specificity	Expressed in neocortical pyramidal cells. Expressed in pancreatic beta cells (at protein level). Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland. Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra.
Cellular localization	Cell Membrane Perikaryon Cell Projection Axon Dendrite Membrane Multi-Pass Membrane Protein Cell Junction Synapse Postsynaptic Cell Membrane Synaptosome Lateral Cell Membrane Sarcolemma Localizes To High-Density Somatodendritic Clusters And Non-Clustered Sites On The Surface Of Neocortical And Hippocampal Pyramidal Neurons In A Cortical Actin Cytoskeleton-Dependent Manner Localizes Also To High-Density Clusters In The Axon Initial Segment (Ais) At Ankyrin-G-Deficient Sites On The Surface Of Neocortical And Hippocampal Pyramidal Neurons Kcnb1-Containing Ais Clusters Localize Either In Close Apposition To Smooth Endoplasmic Reticulum Cisternal Organelles Or With Gaba-A Receptor-Containing Synapses Of Hippocampal And Cortical Pyramidal Neurons Respectively Localizes To High-Density Clusters On The Cell Surface Of Atrial And Ventricular Myocytes And At The Lateral Plasma Membrane In Epithelial Cells Localizes Both To The Axial And Transverse Tubules (T Tubule) And Sarcolemma In Ventricular Myocytes Associated With Lipid Raft Domains In Cortical Neurons Apoptotic Injuries Induce De Novo Plasma Membrane Insertion In A Snare-Dependent Manner Causing An Apoptotic Potassium Current Surge
Molecular weight	90 kDa
Dilution range	IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000
Alternative names	Anti-Potassium Voltage-Gated Channel Subfamily B Member 1 antibody Anti-Delayed Rectifier Potassium Channel 1 antibody Anti-Drk1 antibody Anti-H-Drk1 antibody Anti-Voltage-Gated Potassium Channel Subunit Kv2.1 antibody Anti-KCNB1 antibody
Protein name	Potassium Voltage-Gated Channel Subfamily B Member 1 Delayed Rectifier Potassium Channel 1 Drk1 H-Drk1 Voltage-Gated Potassium Channel Subunit Kv2.1
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	KCNB1_HUMAN

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50ul

Listprice: €121.00

Price: €121.00

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Delivery expected until 8/28/2025

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