Anti-NTRK1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P04629

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

NTRK1

Rabbit polyclonal against NTRK1

Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Late Endosome Membrane
Recycling Endosome Membrane
Rapidly Internalized After Ngf Binding
Internalized To Endosomes Upon Binding Of Ngf Or Ntf3 And Further Transported To The Cell Body Via A Retrograde Axonal Transport
Localized At Cell Membrane And Early Endosomes Before Nerve Growth Factor (Ngf) Stimulation
Recruited To Late Endosomes After Ngf Stimulation
Colocalized With Rapgef2 At Late Endosomes

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

High Affinity Nerve Growth Factor Receptor
Neurotrophic Tyrosine Kinase Receptor Type 1
Trk1-Transforming Tyrosine Kinase Protein
Tropomyosin-Related Kinase A
Tyrosine Kinase Receptor
Tyrosine Kinase Receptor A
Trk-A
Gp140trk
P140-Trka

NTRK1_HUMAN