Anti-CTCF antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P49711

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

CTCF

Rabbit polyclonal against CTCF

Nucleus
Nucleoplasm
Chromosome
Centromere
May Translocate To The Nucleolus Upon Cell Differentiation
Associates With Both Centromeres And Chromosomal Arms During Metaphase
Associates With The H19 Icr In Mitotic Chromosomes
May Be Preferentially Excluded From Heterochromatin During Interphase

WB 1:1000-1:2000 IHC 1:50-1:200 IF 1:50-1:200 ChIP 1:50-1:200

Transcriptional Repressor Ctcf
11-Zinc Finger Protein
Ccctc-Binding Factor
Ctcfl Paralog

CTCF_HUMAN