Anti-SET antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q01105

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene.

SET

Rabbit polyclonal against SET

Cytoplasm
Cytosol
Endoplasmic Reticulum
Nucleus
Nucleoplasm
In The Cytoplasm
Found Both In The Cytosol And Associated With The Endoplasmic Reticulum
The Set Complex Is Associated With The Endoplasmic Reticulum
Following Ctl Attack And Cleavage By Gzma
Moves Rapidly To The Nucleus
Where It Is Found In The Nucleoplasm
Avoiding The Nucleolus
Similar Translocation To The Nucleus Is Also Observed For Lymphocyte-Activated Killer Cells After The Addition Of Calcium

WB 1:500-1:2000

Protein Set
Hla-Dr-Associated Protein Ii
Inhibitor Of Granzyme A-Activated Dnase
Igaad
Phapii
Phosphatase 2a Inhibitor I2pp2a
I-2pp2a
Template-Activating Factor I
Taf-I

SET_HUMAN