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ARV-471

ARV-471

€1,200.00

Excl. VAT

Item no.	M21158-10mg
Manufacturer	AbMole
CASRN	2229711-68-4
Amount	10mg
Category	Reagents & Chemicals Other Chemicals
Type	Chemicals
Specific against	other
Purity	>99%
Formula	C45H49N5O4
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Bioactivity information	ARV-471 is an oral estrogen receptor PROTAC protein degrader for breast cancer.ARV-471 is a heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes.ARV-471 causes ubiquitination and subsequent degradation of the estrogen receptor via the proteasome.ARV-471 potently degrades ER-positive The ER in breast cancer cell lines is potently degraded by ARV-471 with a DC50 value of approximately 2 nM.
mw	723, 9
solubility	DMSO ≥ 60 mg/mL

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mg

Listprice: €1,200.00

Price: €1,200.00

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Delivery expected until 9/11/2025

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