Biotinylated SARS-CoV-2 Spike RBD (L452Q, F490S), His,Avitag™

PBS, pH7.4

It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Arg 319 - Lys 537

28.2 kDa

Biotinylated SARS-CoV-2 Spike RBD, His, Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Biotinylated SARS-CoV-2 Spike RBD, His, Avitag (SPD-C82Eh) is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (L452Q, F490S)). Mutations L452Q, F490S were identified in the SARS-CoV-2 Lambda variant (Pango lineage: C.37).