Recombinant Mouse IgG2A Fc Protein

As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotypethat can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, andconstitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens byagglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked bydisulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fabfragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum amongthe four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragmentis demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A onthe surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and hasnumerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested torepresent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

Proteins

Pro99-Lys330

Fc & Fc receptor

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.Contact us for customized product form or formulation.