Recombinant Mouse LAG-3/CD223 Protein

Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with fourextracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The genefor LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20%identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoiddendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with thebinding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by thisinteraction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays animportant role in Treg suppressive function. LAG3 is the target of various drug development programs todevelop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developedas a cancer drug.

Proteins

Ser23-Leu442

Immune Checkpoint, Bio-Markers & CD Antigens

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.