Recombinant Human TNFRSF14/HVEM Protein

Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it canboth promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophilactivation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding toCD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEMenhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinalepithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilalintegrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membranefusion, can antagonize both BTLA and LIGHT binding.

Proteins

Leu39-Val202

Immune Checkpoint

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.Contact us for customized product form or formulation.