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Recombinant human CTLA-4 protein

Recombinant human CTLA-4 protein

€243.00

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Item no.	NKM-ATGP3914-50ug
Manufacturer	NKMAX
Amount	50ug
Category	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Conjugate/Tag	hIgG-His-Tag
Purity	> 95% by SDS - PAGE
Sequence	<ADL>KAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD<L EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD> <VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDW
NCBI	NP_005205
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, ATGP3364
Available
Activity	Human CTLA-4 inhibits Human B7 1/CD80 induced IL-2 secretion of the Jurkat human acute T cell leukemia cells. The ED50 range ? 150 ng/ml.{ATGP3914-BA.JPG}
Antigen Species	Human
Applications info	SDS-PAGE, Bioactivity
Biological activity	The activity is determined by the IL-2 ELISA in a using Jurkat human acute T cell leukemia cells. The ED50 range ? 150 ng/ml with Human B7 1/CD80.
Concentration	0.5mg/ml (determined by Absorbance at 280nm)
Description	CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA-4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Domain	36-161aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Expression System	Baculovirus
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Category	Immunology
General References	Harper K., et al. (1991) J. Immunol. 147:1037-1044. Teft WA., et al. (2006) Annu. Rev. Immunol. 24:65-97.
Molecular Weight	40.8kDa (368aa)
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50ug

Listprice: €243.00

Price: €243.00

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Delivery expected until 8/28/2025

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